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    Se tillgänglighet Det finstilta. Please note that in case of late arrival after Several vaccine candidates are currently at different stages of preclinical or clinical development [2].

    What were the design and the main objectives of the infant study in South Africa? The study population included in the analysis consisted of BCG-vaccinated, HIV-negative infants aged months, with both study arms almost equally sized.

    Follow-up was up to 37 months. The primary objective of the study was to assess the safety of MVA85A in these infants. The secondary objectives were to evaluate efficacy of the vaccine against a the disease and b M.

    This distinction is important as infection only leads to formal TB disease in a small minority of immune-competent individuals. Additional objectives included the evaluation of immunogenicity.

    Safety, efficacy and immunogenicity results are described in a recent publication. What conclusions can be drawn from the results of the PoC phase IIb trial?

    This is the first clinical trial conducted to evaluate the efficacy of a new TB vaccine candidate against clinical TB or M.

    A metro-like suburban service is also provided on the southern part of the line. Tramway de Nice began operating horse-drawn trams in The replacement of trams with trolleybuses began in and was completed in In , the new Tramway de Nice linked the northern and eastern suburbs via the city centre.

    Two other lines are currently in the planning stage. The A8 autoroute and the Route nationale 7 pass through the Nice agglomeration, linking Marseille with Italy.

    Before Nice was urbanised, the coastline at Nice was just bordered by a deserted stretch of shingle beach covered with large pebbles.

    The first houses were located on higher ground well away from the sea, as wealthy tourists visiting Nice in the 18th century did not come for the beach, but for the gentle winter weather.

    In the second half of the 18th century, many wealthy English people took to spending the winter in Nice, enjoying the panorama along the coast.

    When a particularly harsh winter up north brought an influx of beggars to Nice, some of the rich Englishmen proposed a useful project for them: The city of Nice, intrigued by the prospect of a pleasant promenade, greatly increased the scope of the work.

    After the annexation of Nice by France in it was rechristened La Promenade des Anglais , replacing the former Nissart name with its French translation.

    The Hotel Negresco on the Promenade des Anglais was named after Henri Negresco — who had the palatial hotel constructed in In keeping with the conventions of the time, when the Negresco first opened in its front opened on the side opposite the Mediterranean.

    This section of the city is referred to as the "Zone Pietonne", or "Pedestrian Zone". Cars are not allowed with exception to delivery trucks , making this avenue a popular walkway.

    Today, it is open to the public and provides a regular program of performances. Before the Paillon River was covered over, the Pont-Neuf was the only practicable way between the old town and the modern one.

    The square was thus divided into two parts North and South in The recent rebuilding of the tramline gave the square back to the pedestrians, restoring its status as a real Mediterranean square.

    It is lined with palm trees and stone pines, instead of being the rectangular roundabout of sorts it had become over the years. It is used for concerts, and particularly during the summer festivals, the Corso carnavalesque carnival parade in February, the military procession of 14 July Bastille Day or other traditional celebrations and banquets.

    It is also a large crossroads between several of the main streets of the city: The Place Garibaldi also stands out for its architecture and history.

    It is named after Giuseppe Garibaldi , hero of the Italian unification born in Nice in when Nice was part of the Napoleonic Empire, before reverting to the Kingdom of Piedmont-Sardinia.

    The square was built at the end of the 18th century and served as the entry gate to the city and end of the road to Turin. A statue of Garibaldi, who was fiercely in favour of the union of Nice with Italy, stands in the centre of the square.

    The recent rebuilding of the area to accommodate the new tramway line gave mostly the entire square to pedestrians. The architecture is in line with the Turin model, which was the norm of urban renewal throughout the entire realm of the House of Savoy.

    It is a crossroads between the Vieux Nice old town and the town centre. This square is also a junction of several important streets: Entirely enclosed and pedestrianised, this square is located in the heart of the old town.

    By day, the place is invaded by the terraces of traditional restaurants and the finest ice-cream makers. By night, the environment changes radically, with tourists and youths flocking to the square, where music reverberates on the walls of the small square.

    The square's lighting at night gives it a magical aspect. In the past, it belonged to the upper classes. It is probably the most traditional square of the town, with its daily flower market.

    In the present, the court is mostly a place of entertainment. On this square, there also is the Palais Rusca , which also belongs to the justice department home of the tribunal de grande instance.

    The square is also notable due to the presence of the city clock. Today, the Place du Palais is alive day and night.

    Often, groups of youths will hangout on the steps leading to the Palais de la Justice. Concerts, films, and other major public events frequently occur in this space.

    The metropolitan area of Nice, defined by INSEE, is home to , inhabitants fifth most populous in France and its urban area totals , inhabitants, which makes it the sixth largest in France.

    Since the s, the number of inhabitants has not changed significantly; the relatively high migration to Nice is compensated by a natural negative growth of the population.

    The architect was Charles Garnier , and Gustave Eiffel designed the main dome. The cm inch refractor telescope that became operational in was at that time the world's largest telescope.

    Terra-Amata, an archaeological site dating from the Lower Palaeolithic age, is situated near Nice. Nice itself was established by the ancient Greeks.

    There was also an independent Roman city, Cemenelum, near Nice, where the hill of Cimiez is located. It is an archaeological site with treasures, of which only a small part has been excavated.

    The excavated site includes thermal baths, arenas and Roman road. Nice inspired many composers and intellectuals in different countries e.

    Berlioz , Rossini , Nietzsche etc. Nice also has numerous museums of all kinds: Being a vacation resort, Nice hosts many festivals throughout the year, such as the Nice Carnival and the Nice Jazz Festival.

    Nice has a distinct culture due to its unique history. It is still spoken by a substantial minority. In the past, Nice welcomed many immigrants from Italy who continue to make up a large proportion of the population , as well as Spanish and Portuguese immigrants.

    However, in the past few decades immigration has been opened to include immigrants from all over the world, particularly those from former Northern and Western African colonies, as well as southeast Asia [ citation needed ].

    Traditions are still alive, especially in folk music and dances. The most famous dance is the farandole. The detonation can be heard almost all over the city.

    This tradition goes back to Sir Thomas Coventry, who intended to remind the citizens of having lunch on time. The cuisine of Nice is especially close to those of Provence but also Liguria and Piedmont and uses local ingredients olive oil , anchovies , fruit and vegetables but also those from more remote regions, in particular from Northern Europe, because ships which came to pick up olive oil arrived full of food products, such as dried haddock.

    Nice has a few local dishes. Socca is a type of pancake made from chickpea flour. Local meat comes from neighbouring valleys, such as the sheep of Sisteron.

    Local fish, such as mullets, bream, sea urchins, and anchovies alevins are used to a great extent, so much so that it has given birth to a proverb: Nice is twinned with: People awarded the honorary citizenship of Nice are:.

    Edit Read in another language Nice. This article is about the city in France. For the concept of being nice, see Kindness. For other uses, see Nice disambiguation.

    Greeks in pre-Roman Gaul. This section does not cite any sources. Please help improve this section by adding citations to reliable sources.

    Unsourced material may be challenged and removed. November Learn how and when to remove this template message. Flora Edit This section does not cite any sources.

    July Learn how and when to remove this template message. January Learn how and when to remove this template message. The city's major football club is OGC Nice.

    They play in Ligue 1 the top division in France. The Olympic Nice swimming club French: This section needs to be updated.

    The recent rebuilding of the tramline gave the square back to the pedestrians, restoring its status as a real Mediterranean square. Retrieved 4 November Yerevan Municipality Official Website. Musee International de la Parfumerie. For other beste hauptdarstellerin – drama, see Nice disambiguation. Retrieved 3 April The Treaty of Österreich schweden live stream once more gave the city back to the Duke of Savoy, who was on that same occasion recognised as King of Sicily. Several institutions of higher learning are also located here, along with the European headquarters of W3C. Entirely enclosed and pedestrianised, this square is located in the heart of the old town. The medieval city walls surrounded the Old Town. So, what can be drawn from the absence of a significant efficacy of the vaccine, as shown in Beste Spielothek in Westdorf finden infant trial? Giuseppe Garibaldiborn in Nice, opposed the cession to France, arguing that the ballot was rigged by the French. In addition, the mechanism of WHO prequalification ensures that vaccines supplied to countries through UN agencies meet international standards for quality, safety and efficacy and are appropriate for the target population. Retrieved 4 March Lancet, 4 February ; doi:

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    Thanks for your time! Your feedback will help us improve so you can book more easily next time. Thanks for your response. Just booked in Cannes: See availability Area Info — This neighborhood is a great choice for travelers interested in sunshine, beach walks and promenades — Check location Show map.

    Cannes Palais de Justice - Court House. Private Hospital Cannes Oxford. Notre Dame d'Esperance Church. Most Popular Landmarks Fort Royal.

    Musee International de la Parfumerie. Are you missing any information about this area? Parking No parking available. Pets Pets are not allowed.

    Languages Spoken French English. What topic s do you want to know more about? Follow-up was up to 37 months.

    The primary objective of the study was to assess the safety of MVA85A in these infants. The secondary objectives were to evaluate efficacy of the vaccine against a the disease and b M.

    This distinction is important as infection only leads to formal TB disease in a small minority of immune-competent individuals.

    Additional objectives included the evaluation of immunogenicity. Safety, efficacy and immunogenicity results are described in a recent publication.

    What conclusions can be drawn from the results of the PoC phase IIb trial? This is the first clinical trial conducted to evaluate the efficacy of a new TB vaccine candidate against clinical TB or M.

    In this trial, MVA85A appears to be safe and well tolerated, confirming similar findings from previous phase I and phase IIa clinical trials using this vaccine.

    None of the observed serious adverse events or deaths observed in the study arm were assessed by the sponsors as being related to the vaccine and only one serious adverse event involving brief hospitalization occurred in the placebo group.

    The efficacy analysis is based on the number of TB cases amongst the vaccinated versus control subjects. In the vaccine arm, there were 32 cases, while in the placebo arm there were 39 cases.

    Based on this, the calculated vaccine efficacy is Moreover, there was no evidence of protection against M. What are the implications for future studies of this and other TB vaccine candidates?

    Over-interpretation of phase IIb trial results should therefore be avoided. So, what can be drawn from the absence of a significant efficacy of the vaccine, as shown in this infant trial?

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